A highly moisturising serum formula for an intensive effect on wrinkles and skin elasticity. A synergy of ten biomimetic peptides with a filler-like action combined with platinum, diamond powder and colloidal gold. The topical application of melatonin is a new way of slowing down the effects of ageing related to the skin's melatoninergic system. Liposomes act as vehicles to transport nutrients to the cells. An innovative, high-performance treatment designed to be used together with the Night Time filler serum to minimise the effects of time in an extremely luxurious way. Can also be used on the eye area.
Night time Filler Plus features tripeptides with less than 500-Dalton that can penetrate the dermis and sub-dermal layers without any releasing agent.
Il Palmitoyl sh-Tripeptide-1 Amide
induces skin cell proliferation and the synthesis of collagen and elastin. As an FGF tripeptide (Fibroblast Growth Factor), in the dermal and subcutaneous layers, it provides activation signals in a receptor-compatible manner, thus regenerating collagen and elastin, resulting in improved skin tone, texture and regeneration.
Il Palmitoyl sh-Tripeptide-3 Amide
s an EGF tripeptide (epidermal growth factor), has powerful regenerative properties: it facilitates the growth of keratinocytes, dermal fibroblasts and collagen fibres (collagenesis). It catalyses the skin's natural regeneration process to repair UV-induced stress and oxidative damage.
Il Palmitoyl Tripeptide-54 Amide
a small peptide derived from Adiponectin, facilitates the proliferation of epidermal cells and the generation of ceramides, collagen and hyaluronic acid in the dermis. It also helps form the skin's protective barrier by increasing the expression of filaggrin, a key skin protector.
Il Palmitoyl-SH Tripeptide- 4 Amide
Palmitoyl-SH Tripeptide- 4 Amide by inhibiting inflammatory cytokines, works synergistically with the other peptides in the formulation, for a strong antioxidant action and demonstrates a further soothing effect, in strategic combination with Acetyl Trapeptide-15, providing relief and calming even the most sensitive and reactive skin. Ideal for highly stressed or blemished skin. Acetyl Tetrapeptide-15, donando sollievo e calmando anche le pelli più sensibili e reattive. Ideale per una pelle fortemente stressata anche per la presenza di pustole.
Il Palmitoyl Tripeptide-53 Amide
has a smoothing and preventive action with regards to the formation of blemishes on the skin and limits damage caused by overexposure to UV radiation.
Il Palmitoyl Hexapeptide 19
contributes to the filler-like effect of the formulation, stimulating the action of botulinum toxin in a natural way and with a proven tensor effect.
L’Acetyl Tetrapeptide-17, Acetyl Heptapeptide-9 e l’Acetyl sh-Pentapeptide-35
L’Acetyl Tetrapeptide-17, Acetyl Heptapeptide-9 e l’Acetyl sh-Pentapeptide-35 coniugati all’oro, al platino colloidale e alla polvere di diamante, che fungono da carrier, stimolano la sintesi delle proteine della matrice extracellulare e il metabolismo cutaneo. Oro, platino e diamante hanno una funzione specifica: fungono da scudo protettivo e veicolo per l’assorbimento percutaneo causando un effetto “ritardo” sul rilascio del peptide a cui sono legato, cosi da assicurane la maggiore stabilità ed efficacia.
The topical application of melatonin: Beauty sleep
The neuro-hormone melatonin ( N -acetyl-5-methoxytryptamine) is prominently, though not exclusively, synthesised in the pineal gland and is secreted phasically, as its levels vary with the daily cycle. Melatonin synthesis is a four-stage process that begins with the amino acid l-tryptophan and ends with the production of melatonin.
The melatoninergic system in the skin
Skin cells express all stages of melatonin synthesis and melatonin receptors are present in the skin. The skin is not only a target for the protective action of the molecule but also a site of melatonin synthesis and metabolism.
Chronobiology identifies melatonin as an important regulator of circadian and circannual bio-rhythms, defined by its rhythmic night/day production and variations in the duration of the night-time peak. At a cellular and tissue level, melatonin acts as a modulator of cell proliferation, differentiation and apoptosis.
Our skin has a melatoninergic system with several roles including improving inflammation and promoting wound healing. As we age, there is a decrease in melatonin production and the density of skin receptors. This decrease reduces the skin's ability to effectively utilise this powerful restorative.
The topical application of melatonin is a new way of reversing many of the age-related changes in the skin's melatonin system.
Melatonin is present in liposomal form for greater stability and release. Liposomes act as vehicles to transport nutrients to the cells through the layers of the skin and enhance the delivery of the functional ingredient. Liposomes are readily compatible with epidermal surface lipids, the skin's main moisture barrier. When a liposome fuses with epidermal lipids, the epidermal lipid structure becomes overloaded, presenting an unbalanced situation. To restore the balance, the water and phospholipid, as well as the active ingredient, are rapidly agitated through the upper cell layers of the stratum corneum. Optimal release of the active ingredient occurs because it is rapidly transported along the stratum corneum. The proven delivery system of liposomes offers a multitude of advantages: improving the penetration of functional ingredients more effectively, providing release mechanisms over time and protecting otherwise unstable ingredients.
"Beauty sleep", with the antioxidant protection of melatonin, is linked to this powerful natural restorative to recharge the skin's radiance and strengthen its ability to repair, renew and revitalise.
HOW TO USE
Dopo la detersione, stendere sul viso, collo e décolleté, una/due gocce di siero e massaggiare delicatamente fino a completo assorbimento. Utilizzare il prodotto di notte in combinazione con il Night Time filler per una azione d’urto sulle rughe e l’elasticità cutanea. Il prodotto può essere usato anche sull’area perioculare.
Dermocosmetic product for external use. Do not use on irritated skin. Avoid contact with the eyes. Keep out of reach of children. Store in a cool, dry place, away from heat sources. Do not expose to sunlight. The product should not be used if there is an established individual hypersensitivity to the product or any of its ingredients. A change in colour is normal and due to the naturalness of the product.